Atkinson stumbled upon this drug interaction while developing a new drug containing acetaminophen, ibuprofen (the main ingredient in Advil) and phenylephrine. Ibuprofen does not cause harmful side effects when combined with phenylephrine, he said.
What other drugs will affect phenylephrine?
- other decongestants, including nasal sprays;
- digoxin (digitalis, Lanoxin);
- medicine to treat diabetes;
- medicines to treat high blood pressure such as reserpine, methyldopa (Aldomet), and others;
It's the active ingredient in dozens of generic products, including children's cough medications and over-the-counter (OTC) drugs. Some of the most commonly used medications that contain phenylephrine include Neo-Synephrine, Sudafed PE, Vicks Sinex Nasal Spray, and Suphedrine PE.
Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID). Ibuprofen works by reducing hormones that cause inflammation and pain in the body. Phenylephrine is a decongestant that shrinks blood vessels in the nasal passages. Dilated blood vessels can cause nasal congestion (stuffy nose).
Phenylephrine is usually taken every 4 hours. Follow the directions on the medicine label. Never take more of the medicine than directed on the label or prescribed by your doctor. Call your doctor if your symptoms do not improve after 7 days of using phenylephrine, or if they get worse and your also have a fever.
To keep your blood pressure in check, avoid over-the-counter decongestants and multisymptom cold remedies that contain decongestants — such as pseudoephedrine, ephedrine, phenylephrine, naphazoline and oxymetazoline. Instead: Choose a cold medication designed for people who have high blood pressure.
Overdose symptoms may include severe dizziness or drowsiness, slow heart rate, and fainting. Since phenylephrine nasal is used when needed, you may not be on a dosing schedule. If you are on a schedule, use the missed dose as soon as you remember.
Serious Side Effects of Phenylephrine:
- Fast, pounding, or uneven heartbeat.
- Swelling of your face, lips, tongue, or throat.
- Difficulty breathing.
- Severe dizziness or anxiety.
- Easy bruising or bleeding, unusual weakness, fever, chills, body aches, or flu symptoms.
- Dangerously high blood pressure.
No interactions were found between ibuprofen and Sudafed PE Congestion. This does not necessarily mean no interactions exist. Always consult your healthcare provider.
It may increase your risk of stomach bleeding. Avoid taking aspirin while you are taking ibuprofen. Many combination medicines contain ibuprofen or pseudoephedrine. Taking certain products together can cause you to get too much of ibuprofen and pseudoephedrine.
TYLENOL COLD MULTI-SYMPTOM NIGHTTIME OTC. Generic Name and Formulations: Acetaminophen 325mg, chlorpheniramine maleate 2mg, dextromethorphan HBr 10mg, phenylephrine HCl 5mg; per Cool Burst caplet.
SUDAFED PE® Sinus Pressure + Pain. Non-drowsy decongestant provides powerful relief of sinus congestion and pressure with pain, plus headaches. Each maximum strength tablet contains acetaminophen for pain relief and phenylephrine HCI.
Acetaminophen is a pain reliever and a fever reducer. Pseudoephedrine is a decongestant that shrinks blood vessels in the nasal passages. Dilated blood vessels can cause nasal congestion (stuffy nose). Acetaminophen and pseudoephedrine may also be used for purposes not listed in this medication guide.
Ask a doctor or pharmacist before using any other cold, allergy, pain, or sleep medication. Acetaminophen (sometimes abbreviated as APAP) is contained in many combination medicines. Taking certain products together can cause you to get too much acetaminophen which can lead to a fatal overdose.
Acetaminophen 325mg, pseudoephedrine HCl 30mg; per liquid cap; contains sodium 16mg/cap.
Symptoms of overdose may include: nausea, vomiting, loss of appetite, sweating, stomach/abdominal pain, extreme tiredness, agitation, confusion, flushing, hallucinations, yellowing eyes/skin, dark urine, seizures.
Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID). Ibuprofen works by reducing hormones that cause inflammation and pain in the body. Pseudoephedrine is a decongestant that shrinks blood vessels in the nasal passages. Dilated blood vessels can cause nasal congestion (stuffy nose).
No interactions were found between Sudafed 24-Hour and Tylenol. This does not necessarily mean no interactions exist. Always consult your healthcare provider.
Yes, you can safely take acetaminophen and ibuprofen together. Research studies have shown that ibuprofen (Advil, Motrin) and acetaminophen (Tylenol) together work well to relieve certain types of pain with few side effects.
The antihistamine works on the altered immune function giving the allergy symptoms and the Decongestant, pseudofed, causes nasal arterial constriction. The true story is that their migraine headache, caused by vasodilatation of arteries in the brain, is better following the vasoconstrictor effect of pseudofed.
In some cases, pain relievers can work side-by-side with cough and cold medicines to ease symptoms like headaches, body aches, and fever. But such combined products pose a serious risk: accidentally overdosing on acetaminophen, ibuprofen, or other pain drugs if you take more than one medication.
Acetaminophen is a pain reliever and a fever reducer. The combination of acetaminophen and guaifenesin are used to treat headache, aches and pains, fever, and chest congestion caused by common cold or flu. It also loosens phlegm (mucus) in your chest to help you breathe more easily.
Interactions between your drugs
No interactions were found between Mucinex and Tylenol Sinus Severe Day. This does not necessarily mean no interactions exist. Always consult your healthcare provider.It affects the signals in the brain that trigger cough reflex. Acetaminophen and dextromethorphan is a combination medicine used to treat cough and pain or fever caused by the common cold or flu. Acetaminophen and dextromethorphan may also be used for purposes not listed in this medication guide.
Interactions between your drugs
No interactions were found between Mucinex and phenylephrine. This does not necessarily mean no interactions exist. Always consult your healthcare provider.
